Objectives To study expressions of adhesion molecules in rats with overtraining-induced a-cute kidney injury and the protective efect of scoplamine on the damage. Methods The animal medel of renal damage induced by overtraining was developed by exhaustive swimming. The changes of renal function were meas-ured. The renal tissue structure was observed by microscopy. Immunohistothemieal technigue was used to estimate the expression of ICAM-1 ,E-cadherin,in renal tissue and the. Results Were analyzed semi-quantitatively with the pathological image analysis system. The serum biochemical parameters,such as BUN and CK increased immedi-ately after exhausted rat. It was more prominent at 6 hour and recovered to the normal at 24 hour. R-GT in the urine was increased at 12 and 24 hours after exhausted rat. The morphologie changes were slight under light micrescopy in HE staining. After using of scoplamine,compared with that of control rats, renal function was improved, no morpholog-ic changes can be found. Expressions of ICAM-1 were increased gradually in the glomeruli and tubules of kidneys in S group rats following the time continued after exhausting exercise. But expressions of E-cadherin and 13-Catenin were contrary to ICAM-1. Their expressions were reduced signifieantly in $24 group than N group(p <0.01).After treated with scopolamine , those levels of adhesion molecules were not significant difference from those of N group rats(p <0.05). Conclusions Renal damage could be induced by exhaustive swimming,These changes of adhesion molecules are the important pathogenesis of overtmining-induced acute kidney injury, scopolamine had the protective elect on the damage.