Objectives To investigate the relationship between hypertension and removal of sodium,extracellular volume in patients treated with traditional hemodialysis modality. Methods Hemodialysis group: all the patients in our hemodiaysis unit treated with traditional hemodialysis modality(3 times per week)for at least 3months were selected(n =98) , the values of blood pressure, serum sodium, proportion of weight loss to the weight before hemodialysis and the dry weight were registered. No dialysis group: all the in patients with CKD4 or CKDS who never received any modality of renal replacement therapy were selected (n = 118) , the values of blood pressure, serum sodium on the admission day were also registered. All the acquired data from each group were analysised and statistics with SPSS. Results Blood pressure was better controlled in hemodailysis patients compared with the patients in no dialysis group(X2 = 10.767, p =0.001). Serum sodium correlate with hypertension in all the cases in 2 groups(re = 0.151, p =0.027) , but no relationship between them in each group. Blood pressure was lower in patients who have attained dry weight compared with patients who have not attained dry weight (X2 = 16.450, p < 0.01). Conclusions Lower salt intake, convection depended on the prescribed ultrafiltration together with diffusion occurred across the dialyzer membrane based on the dialysate sodium and serum sodium consist the best protocol to attain the balance of systemic sodium and control the blood pressure in patients with traditional hemodalysis.