Objectives To summarize diagnostic and therapeutic experience of chronic prostatitis combined with varicocele. Methods 526 varicocele patients with chronic prostatitis underwent superselective high ligation of the internal spematic veins. After operation,all the patients had individual treatment in 4-8weeks according to the type of CP and Chronic Prostatitis Symptom Index(CPSI). Results The diameter of spermatic vein＜1.8mm in 468 cases, while the diameter of spermatic vein ＞ 1.8mm in 58 cases in 3 months after operation. The CPSI scor e in 526 patients was decreased from 19.2 ±4.8 before treatment to 4.8 ± 3.4 after treatment. CPSI score decreased by 15.8. Routine examination of the prostatic secretions became normal in 388 cases(73.3% ) ,and bacterial culture became negtive in 146 cases(79.7% ). There was significant difference before and after operation. Conclusions In CP patients combined with VC, the curative effect was improved by superselective high ligation of the internal spematic veins.