Objectives To evaluate the effects of combined therapy for chronic bacterial prostatitis. Methods A total of 226 patients with chronic bacterial prostatitis were randomly divided into 2 groups. Group A:transurethral perfusion combined with external high frequency thermotherapy. Group B: Combination therapy of antibiotherapy and Prostat. The treatment course for each group was 2 months.The therapeutic effects of the 2 therapies were compared and analyzed. Results The arerage CPSI scores in group A and B were reduced by 15.1、12.1 respectively; the rates of the patients( EPS＜10/HP) in each group were 76% and 70% respectively; the bacterium negative rates in Group A and B were 76.9% and 65.2% respectively. Conclusions The curative effect of transurethral perfusion combined with external high frequency thermotherapy was better than that of Combination therapy of antibiotherapy and Prostat.