Objectives To investigate our experience in the early observation and nursing countermeasures of urinary sepsis after endoscopic lithotripsy for female patients with upper urinary tract calculi.Methods Tthe clinical date of 22 female patients with upper urinary tract stones who have urinary sepsis after endoscopic lithotripsy from May 2013 to December 2015 were collected.The preoperative condition,the change state of illness during and postoperation and the nursing countermeasure of patients were retrospectively analyzed.Results A total of 21 patients were discharged from hospital upon recovery after timely and efficiently symptomatic treatment and active nursing,and 1 patient died because of serious infections and multiple organ dysfunction syndrome.Conclusions We should pay attention to susceptible factors of urosepsis,and early diagnosis and active treatment can improve the incidence of rescue rate of urinary sepsis.