Dendricity in normal human melanocytes is a fundamental requirement for melanosome transfer to keratinocytes, for which melanocyte-keratinocyte contact and adhension is a prerequisite. The morphological changes in melanocytes, including the size of melanocytes and elongation and retraction of dendrite tips, are associated with reorganization of actin filaments and microtubules.Rho small GTPases consist of 20 members， of which RhoA, Rac1 and Cdc42 take center stage. Many studies have shown that RhoA, Rac1and Cdc42 play a critical role in the regulatory mechanism of actin cytoskeletal organization and cell-cell or cell-substratum adhension.