Objective: To observe the clinical effect of vitamin AD drops combined with iron proteinsuccinylate oral solution in the treatment of iron deficiency anemia in infants. Methods: A total of 102 children of both sexes with iron deficiency anemia in our children’s health clinic were equally and randomly allocated into an observation group(n=52) and a control group(n=50). Th e observation group was treated with iron proteinsuccinylate oral solution combined with vitamin AD drops orally, and the control group was just treated with iron proteinsuccinylate oral solution orally. Before the treatment, the serum vitamin A and 25-hydroxyvitamin D deficiency in children with iron deficiency anemia were analyzed. Th e treatment effects were compared and the anemia related indicators were also analyzed and compared between the 2 groups 1 month aft er the treatment. Results: Serum vitamin A and 25-hydroxyvitamin D deficiency were serious lack in children with iron deficiency anemia before the treatment. After the treatment, the treatment effective rate of the observation group was 61.54%, which was significantly higher than that of the control group(44%)(P<0.05);the total treatment effective rate was 94.23%, which was also significantly higher than the control group(84%)(P<0.05). Hemoglobin, serum iron and serum ferritin were significantly improved compared with the control group(P<0.05). Conclusion: Vitamin AD drops combined with iron proteinsuccinylate oral solution for the treatment of iron deficiency anemia in infants can effectively improve the anemia indicators associated and significantly improve the efficiency of clinical treatment.