Objective: To observe the validity and feasibility of Nursing Delirium Screening Scale(Nu-DESC) in evaluating delirium of elderly patients undergoing hip replacement in post-anesthesia care unit(PACU). Methods: Th ree hundred patients undergoing hip replacement with general anesthesia admitt ed in PACU were evaluated by NuDESC and the Confusion Assessment Method for the Intensive Care Unit(CAM-ICU) to incidence of postdelirium. Based on CAM-ICU criterion, the feasibility, specificity and sensitivity of Nu-DESC were assessed. Results: A total of 300 patients were participated in this study, 64 cases were diagnosed delirium. Compared with undelirium group, operation time, anesthesia time and PACU time were significantly prolonged;compared with CAM-ICU method, the specificity and sensitivity of Nu-DESC were 92.4% and 67.2%, respectively. Conclusion: Nu-DESC is a simple and feasible. This method can be used to evaluate the initial screening of postoperative delirium in the elderly patients undergoing hip replacement with general anesthesia in PACU.