The specific architecture of podocyte cytoskeleton plays a unique role in the glomerular filtration barrier,which regulate the shape,structure and the ability to response environmental stimuli.The processes of podocyte are consisted of primary and secondary parts.A primary processes of podocyte is supported by intermediate filaments and microtubules,while the secondary processes are mainly supported by actin filaments.Even a slight impairment of the cytoskeleton will lead to proteinuria and glomerular diseases.It is possible to find the therapic target from the cytoskeleton proteins in the related glomerular diseases.