SIRT7 is a member of the nicotinamide adenine dinucleotide(NAD+)-dependent protein deacetylase sirtuin family and a highly specific deacetylation of H3 K18 Ac(acetylated 18-position lysine residue of histone H3). Enzymes are key mediators of many cellular activities. There is increasing evidence that the basic cellular procedural function of SIRT7 has an important impact on oncogenic transformation and tumor biology, so SIRT7 is expected to become a new target for epigenetic drug therapy. Here, we describe the biological role of SIRT7 and summarize the key role of SIRT7 in various types of tumors.