In recent years, more and more studies have shown that obesity is closely related to the increase in blood pressure. In view of the increase in the prevalence of obesity and obesity-related diseases worldwaid, the pathophysiological mechanism of the development between the two is of great significance for the diagnosis, prevention and treatment of hypertension in the obese people. However, there are different diagnostic criteria for obesity in different regions. Th e pathophysiological mechanism of obesity related hypertension is related to the complex influence of neurohumoral factors such as sympathetic nervous system activation, renin-angiotensin-aldosterone system(RA AS) activation, leptin resistance, orexin overexpression, and so on. Cardiovascular system damage in obesity related hypertension patients should not be overlooked. Internet health intervention, surgical treatment and reasonable choice of antihypertensive drugs also provide new ideas for prevention and treatment of obesity related hypertension.