A case of plexiform schwannoma of the penis was retrospectively analyzed by light microscopy and immunohistochemistry(IHC). Th e patient was hospitalized for painless mass of the penis. Microscopically, the tumor was composed of multiple nodules with fibrous connective tissue septum. Th e nodules were composed of Schwann cells in the bundle area(Antoni A), with palisade structure and a litt le mucoid stroma around them. Th e tumor cells expressed Vimentin and S-100, but not glial fibrillary acidic portein(GFAP). CD34 was expressed in the surrounding mucoid stroma. Plexiform schwannoma of the penis is rare and difficult to diagnose clinically. A definite diagnosis requires extensive pathological sampling and IHC detection. Surgical resection is the main treatment with good prognosis.