To explore the application value of intercostal nerve anterior skin branch block in early analgesia after breast cancer surgery. Methods98 patients with radical mastectomy were randomly divided into two groups:the combined group and the control group. The control group received intercostal brachial block analgesia after operation, and the combined group was treated with anterior intercostal nerve block analgesia on the basis of the control group. The cumulative dosage of morphine, visual analogue pain scale (VAS), t-lymph level, cortisol, angiotensin Ⅱ, norepinephrine and epinephrine were compared between the two groups 24 hours after operation. ResultsThe cumulative morphine dosage at 24 hours in the combined group was lower than that in the control group (P＜0.05). VAS scores in the combined group were lower than those in the control group at 4 h and 24 h after operation in the resting state and 4 h and 12 h after operation in the cough state (P＜0.05). The levels of CD3＋, CD4＋/CD8＋ in the combined group were higher than those in the control group 24 hours after operation, and the levels of cortisol, angiotensin Ⅱ, norepinephrine and epinephrine in the combined group were lower than those in the control group (P＜0.05). ConclusionIntercostal nerve anterior cutaneous branch block and intercostal brachial block has good analgesic effect in early postoperative analgesia for breast cancer patients. Reducing surgical trauma has a certain impact on patients' immune system and stress response.