Renal cell carcinoma（RCC） is one of the common tumors of the urinary system ，the incidence of which is increasing year by year. Currently，there is no specific tumor marker for diagnosis of RCC. Surgery is still the most effective treatment for RCC due to its tolerance to radiotherapy，chemotherapy and immunotherapy. Long non-coding RNA（LncRNA） is a non-coding RNA with molecular weight more than 200 nucleotides which doesn’t encode protein. Recently found that LncRNA could be used as a marker of renal cancer and showed promising value in neogenesis，progression and diagnosis of tumors，which provides a new inspiration for diagnosis and treatment of RCC. This review focused on the research progress of LncRNA in diagnosis，treatment and prognosis of RCC.