Objective?To observe the effect of revival quality and analgesia after operation of Oxycodone multimodal analgesia (MMA) in gynecological laparoscopic operation.?Methods?40 patients underwent gynecological laparoscopic oophorocystectomy were randomly divided into two groups: Oxycodone group (Oxy group) and Fentanyl group (Fen group). All patients were receieved Parecoxib by intravenous injection before general anesthesia induction. The induction and maintenance were routine. Five minutes before the end of operation, stop maintenance Propofol and Remifentanil, Oxy group: Oxycodone 0.10 mg/kg + Parecoxib 40 mg intravenous; Fen group: Fentanyl 1.0 μg/kg + Parecoxib 40 mg intravenous. Awake time, tracheal extubation time, environmental interpretation recovery time, cough score, Ramsay score, nausia and vomiting incidence, hemodynamics durning operation and VAS after the surgery of the two groups were recorded.?Results?Two groups have no difference in awake time, tracheal extubation time, environmental interpretation recovery time (P > 0.05); however, cough score in Oxy group was lower than Fen group (P < 0.05), Ramsay score in Oxy group was higher than Fen group (P < 0.05). The systolic blood pressure at T1 and T2 in Oxy group were lower than Fen group (P < 0.05), VAS score of Oxy group at 6 h and 12 h after operation were lower than Fen group (P < 0.05).?Conclusion?Multimodal analgesia of Oxycodone combined with Parecoxib is effective to enhance revival quality and alleviate the pain during the 12 h after gynecological laparoscopic operation.