Objective To analyze the clinical effect of stent intervention combined with thrombus aspiration in the treatment of acute occlusive cerebral infarction.Methods Eighty-five patients with acute occlusive cerebral infarction in Hebi People's Hospital were divided into control group (42 cases) and experimental group (43 cases), and were treated with stent thrombectomy alone or stent intervention combined with thrombectomy.Results The total effective rate and the success rate of vascular recanalization in experimental group were 93.02% and 90.70%, respectively, which were significantly higher than 73.81% and 61.90% in control group (P<0.05). NIHSS scores of experimental group (14.73±3.51 points, 11.16±2.10 points and 7.32±1.53 points) were significantly lower than those of control group (17.82±3.85 points, 15.24±2.15 points and 11.91±2.07 points) on the 1st, 7th and 30th day after treatment. On the 7th and 30th day after treatment, Barthel scores of experimental group (68.63±7.34 points and 88.62±8.61 points) were significantly higher than those of control group (51.87±5.82 points and 64.72±6.59 points), and the difference between groups was significant (P<0.05).Conclusion Stent intervention combined with thrombolysis in the treatment of acute occlusive cerebral infarction has high efficacy, high success rate of vascular recanalization, obvious improvement of nerve function defect, and remarkable improvement of daily living ability.